A/G Ratio Blood Test: Normal Range & High or Low Meaning

A low A/G ratio means globulin is high relative to albumin. This can reflect chronic inflammation, infection, liver disease, kidney disease, or (less commonly) autoimmune conditions or certain blood cancers. It's a signal to investigate, not a diagnosis.

A mildly abnormal A/G ratio is often not significant on its own, especially if albumin, globulin, and total protein are otherwise normal. Your doctor interprets it in the context of your full panel and symptoms.

A high A/G ratio means you have relatively more albumin than globulin than expected. It's less common than a low ratio and can reflect low globulin production, certain genetic conditions, or, occasionally, an underactive immune response. A high ratio on its own is rarely dangerous but is reviewed alongside your total protein, albumin, and globulin levels.

A low albumin/globulin ratio means globulin is elevated relative to albumin, which can reflect chronic inflammation, infection, liver disease, kidney disease, or, less commonly, autoimmune conditions or certain blood cancers. It's a screening clue rather than a diagnosis, and your doctor typically follows up with protein electrophoresis or other targeted testing, alongside your total protein, to pinpoint the cause.