A/G Ratio in a Blood Test: Normal Range & What High or Low Means
Also known as: Albumin globulin ratio, A/G ratio blood test
The A/G ratio is the amount of albumin in your blood divided by the amount of globulin — two families of proteins measured on a metabolic panel. It gives a quick snapshot of protein balance related to liver function, kidney health, and inflammation. A normal A/G ratio is roughly 1.1 to 2.5, meaning you normally have a bit more albumin than globulin.
A/G Ratio normal range
| Category | Range (ratio) |
|---|---|
| Normal | 1.1–2.5Slightly more albumin than globulin |
| Low | < 1.1More globulin relative to albumin |
| High | > 2.5Relatively low globulin |
Reference ranges vary by laboratory. Use the range printed on your own report as the definitive comparison.
What high A/G Ratio can mean
- Low globulin production
- Some genetic conditions
- Occasionally seen with an underactive immune response
What low A/G Ratio can mean
- Liver disease (reduced albumin production)
- Kidney disease (albumin lost in urine)
- Chronic inflammation or infection (raises globulins)
- Some autoimmune conditions and, rarely, blood cancers like multiple myeloma
What to do about an abnormal result
- The A/G ratio is a screening clue, not a diagnosis — abnormal values prompt more specific tests.
- If low, your doctor may order protein electrophoresis to see which proteins are off.
- Review it alongside total protein, albumin, and globulin individually.
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Frequently asked questions
What does a low A/G ratio mean?
A low A/G ratio means globulin is high relative to albumin. This can reflect chronic inflammation, infection, liver disease, kidney disease, or (less commonly) autoimmune conditions or certain blood cancers. It's a signal to investigate, not a diagnosis.
Should I worry about a slightly abnormal A/G ratio?
A mildly abnormal A/G ratio is often not significant on its own, especially if albumin, globulin, and total protein are otherwise normal. Your doctor interprets it in the context of your full panel and symptoms.
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Medically reviewed by Antonieta Rueda, MD and Ayham Shneker, MD · Last reviewed July 6, 2026
This article is for informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or your lab results.